• Recently profound therapeutic efficacy of

  2018-10-24

  

  Recently, profound therapeutic efficacy of intratracheally transplanted bone marrow-derived Mφ has been demonstrated in two murine disease models of herPAP, indicating a therapeutic potential also of iPSC-derived Mφ (Happle et al., 2014; Suzuki et al., 2014a). In this context genetically repaired hu

• br Results br Discussion The interest

  2018-10-24

  

  Results Discussion The interest in directed cell-fate determination in stem cell biology and regenerative medicine has been increasing over the years. However, due to the complexity of GRNs, identification of cell-fate determinants and their functionally important subnetworks (GRN motifs) that

• RNA seq of SCs reinforced transcriptional dynamics

  2018-10-24

  

  RNA-seq of SCs reinforced transcriptional dynamics observed from whole tissues, whereby in the early period, immune-response and chemokine transcripts were upregulated, followed by proliferation and differentiation during the middle time period. Several TFs associated with quiescent ginsenoside rg3

• Previously it was demonstrated that induced NP

  2018-10-24

  

  Previously, it was demonstrated that induced NP (iNPs) can be directly converted from mouse somatic smad inhibitor by overexpressing various TF combinations (Han et al., 2012; Kim et al., 2011; Lujan et al., 2012). Kim et al. (2011) first demonstrated that expandable iNPs could be generated from FB

• We functionally screened spontaneously active CMs for pacema

  2018-10-24

  

  We functionally screened spontaneously active CMs for pacemaker properties, revealing that the majority of such glucosamine sulfate had ventricular- or atrial-like but not nodal-like properties, when APs were elicited from physiological resting potentials (−80 mV). Nav1.5 is the main sodium channel

• br Experimental Procedures See Supplemental Experimental Pro

  2018-10-24

  

  Experimental Procedures See Supplemental Experimental Procedures for additional details. Author Contributions Acknowledgments Derivation and characterization of H1-ECs and RNA-seq experiments were supported by NIH in collaboration with the Defense Advanced Research Projects Agency and the

• Finally we demonstrate here that PML

  2018-10-24

  

  Finally, we demonstrate here that PML promotes iPSC generation by facilitating the early activation steps. Our proposed model for its contribution to reprogramming is that PML activates mesenchymal marker activation (EMT), which in turn enhances epithelial (MET) and pluripotent gene activation, res

• Acknowledging these and other concerns in the International

  2018-10-24

  

  Acknowledging these and other concerns, in 2016 the International Society for Stem Cell Research (ISSCR) updated its 2006 Guidelines for the Conduct of Human Embryonic Stem Cell Research and its 2008 Guidelines for Clinical Translation of Stem Cells to develop a comprehensive guidance document for s

• Scanners with LIDE LED indirect exposure are

  2018-10-24

  

  Scanners with LIDE (LED indirect exposure) are an improved version of the CIS technology. Here the light source uses powerful tri-color RGB (Red, Green, Blue) LEDs, and the radiation is directed to the object via quartz fibers ensuring uniform exposure over the entire width of the original scanner w

• br Results The study population that is included is

  2018-10-24

  

  Results The study population that is included is fairly similar to the entire Swedish population born 1934 to 1959 (Table 1). Those who were excluded from the analyses were more likely to be born at the beginning of the period and lack information on the variables of interest, or to be born at th

• Wicksell picked up the discussion of the effects

  2018-10-23

  

  Wicksell picked up the discussion of the effects of technical progress on distribution from where he had left it in 1890. Wicksell (1890, p. 257, n. 1) had complained that “any fully satisfactory and comprehensive treatment of the problem, once discussed in such a lively manner, of machinery\'s bene

• The major drawback of ARTs is

  2018-10-23

  

  The major drawback of ARTs is the potential of malaria parasites to escape from treatment after a few days, favoring the selection of drug-resistant parasites. This is the reason of the introduction of artemisinin-based combined therapies (ACTs) to treat malaria. These treatments are based on the as

• natural aromatase inhibitors In vitro high concentrations of

  2018-10-23

  

  In vitro, high concentrations of palmitate, glucose, or both combined cause beta cell endoplasmic reticulum (ER) stress and apoptosis. Beta cell ER stress is a known feature of type 2 diabetes in humans and animal models (). Cells respond to ER stress by activating the unfolded protein response (UPR

• Convincing vaccine hesitant patients to be vaccinated requir

  2018-10-23

  

  Convincing vaccine-hesitant patients to be vaccinated requires a response to GPs\' VH. Necessary steps include both better training and updating of GPs\' knowledge of vaccines\' benefits and risks: more time must be devoted to thymidine phosphorylase inhibitor during medical studies than is current

• This hypothesis also provides some insight into more

  2018-10-23

  

  This grams to moles calculator also provides some insight into more pronounced beneficial effects of low alcohol consumption on the risk of AP in women compared to men. Specifically, women are more likely to develop biliary problems and gallstones (Shen et al., 2013; Russell et al., 1998) and there

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