• Although the disease specific phenotype identified in

  2018-10-20

  

  Although the disease specific phenotype identified in this study will be invaluable for demonstrating the efficacy of gene based therapeutics, two major questions remain: 1) why do some patients with TRNT1 variants develop the severe syndromic disease SIFD while others (i.e. the three presented in t

• br Author contributions br Resource table Resource details P

  2018-10-20

  

  Author contributions Resource table. Resource details Previously we have generated an induced pluripotent stem cell line (named MHHi002-A) from a male CF patient homozygous for the mutation p.Phe508del in the CFTR gene. Thereby the absence of the three bases CTT results in the deletion of phe

• If nestin cells do generate new neurons and DA neurons

  2018-10-20

  

  If nestin+cells do generate new neurons and DA neurons within the microenvironment of the adult midbrain, knowledge about their ontogenesis will be crucial to identify signaling mechanisms regulating neurogenesis and DA neurogenesis here, which might help progress cell-replacement therapies for PD.

• br Experimental Procedures br Author Contributions br Acknow

  2018-10-20

  

  Experimental Procedures Author Contributions Acknowledgments Introduction Induced pluripotent stem order orexin (iPSCs) have similar properties as embryonic stem cells (ESCs), such as self-renewal and differentiation capacity (Park et al., 2008c; Takahashi and Yamanaka, 2006). Reprogram

• br Results br Discussion We examined

  2018-10-20

  

  Results Discussion We examined gene expression in human intestinal tissue across the developmental continuum in order to determine maturity of in-vitro-derived HIOs. Using global RNA expression data obtained by RNA-seq, several different analyses demonstrated that the HIO transcriptome closely

• IL IL E is a member

  2018-10-20

  

  IL-25 (IL-17E) is a member of the IL-17 family (Iwakura et al., 2011). However, unlike IL-17A or F, the better-known members of this IL family that have direct roles in autoimmune and chronic inflammatory diseases, IL-25 actually appears to protect against IL-17A/Th17 and Th1 states (Caruso et al.,

• These studies add to a growing body of

  2018-10-20

  

  These studies add to a growing body of information related to the role of p38 MAPK signaling in skeletal muscle progenitor cells. Over a decade ago, a requirement for p38 in the regulation of rodent myoblast differentiation was defined (Cuenda and Cohen, 1999; Zetser et al., 1999). Based on these pr

• br Results br Discussion Many small molecules including two

  2018-10-20

  

  Results Discussion Many small molecules, including two reported by our group (Lee et al., 2013b), have been suggested to be selectively toxic to PSCs. However, as described previously (Knoepfler, 2009), despite the high potency and efficacy of small molecules that target hPSC-specific genes (e

• Over the last few years gene editing by homologous

  2018-10-20

  

  Over the last few years, gene editing by homologous recombination (HR) has been widely used in human alizarin to avoid undesirable transgene insertion. HR efficacy is very limited in human cells, estimated at one HR event per 106 cells; however, the potential application of HR in human cells has be

• br Results br Discussion Pluripotent stem cells

  2018-10-20

  

  Results Discussion Pluripotent stem csf-1r offer unprecedented potential for regenerative medicine as they can be differentiated by a specific sequence of signals to become any cell type of the body. At the same time, any cell product generated from them confers a substantial risk for neoplas

• Introduction The correct functioning of the

  2018-10-20

  

  Introduction The correct functioning of the epigenome ensures fidelity in the establishment of gene-expression programs that are compatible with specific cell identities. The need for tightly controlled epigenetic landscapes is of critical importance for stem cells, which are able to both self-rene

• br Results br Discussion In the present

  2018-10-20

  

  Results Discussion In the present study we show that LPA1 is expressed by stem and progenitor Elesclomol (predominantly type 1 and type 2a) within the neurogenic niche of the dentate gyrus of adult mice, and that it outperforms Nestin, the current gold standard, as a marker for prospective is

• Finally we tested whether the B cell differentiation defect

  2018-10-20

  

  Finally, we tested whether the B cell differentiation defect in the OsxCre;iDTR mutants could be rescued in vivo by intravenous administration of recombinant IL-7 and IGF-1. Both controls and mutants were subjected to daily injections of DT, DT + IL-7, or DT + IGF-1 for 12 days. At the end of the re

• br Introduction Newborn neurons are continuously generated t

  2018-10-20

  

  Introduction Newborn neurons are continuously generated throughout life in several areas of the mammalian brain, including the subgranular zone (SGZ) of the hippocampal dentate gyrus (Imayoshi et al., 2008; Palmer et al., 1997; Zhao et al., 2008). Adult hippocampal neurogenesis is essential for n

• IGF and PI K signaling

  2018-10-20

  

  IGF and PI3K signaling in regenerating muscle was tightly regulated across multiple levels and temporally, especially during the transition between myoblast proliferation and differentiation. In the early period, IGF1 was upregulated and quickly followed by increases in expression and chromatin remo

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