• In addition this study also showed no obvious

  2022-01-07

  

  In addition, this study also showed no obvious increase in apoptosis but obvious increase in necrosis after WZB117 treatment. The possible reason is that apoptosis is an ATP-utilizing process which is an active and programmed form of cell death. In contrast, necrosis is an uncontrolled or pathologic

• Whereas accurate measurement of glucagon

  2022-01-07

  

  Whereas accurate measurement of glucagon in humans has been possible since the early 1950s proper measurements in rodents, have not. That said, plasma concentrations of glucagon have been reported in rodent studies [21] using C-terminal specific methods but what has been lacking is the secretory dyn

• Developmental studies have reported that some subunits

  2022-01-07

  

  Developmental studies have reported that some subunits of GABAA receptors like α2 and α3 are predominantly expressed during in-utero development, and then substituted for α1 around birth in the rat hippocampus (Brooks-Kayal et al., 2001; Fritschy et al., 1994; Golshani et al., 1997; Kapur and Macdon

• Compounds were tested for GPR

  2022-01-07

  

  Compounds , were tested for GPR40 activity in a functional assay monitoring calcium flux in CHO SR 2211 transiently transfected with human GPR40 gene. As shown in , compound was found to be a nanomolar GPR40 agonist, while compound was much less potent than . To explore the structure activity relati

• br Fenton reaction based nanomaterials for ferroptosis In

  2022-01-07

  

  Fenton reaction-based nanomaterials for ferroptosis In Fenton reaction, H2O2 is converted by Fe2+ or Fe3+ to highly oxidative ROS (Eqs. (1) and (2)), which is commonly used to catalyze the degradation of refractory organics [34]. Since the tumor microenvironment is characterized by low acidity an

• br Results br Discussion Impaired BBB

  2022-01-07

  

  Results Discussion Impaired BBB functions evoke vasogenic edema, which elevates intracranial pressure and leads to a life-threatening condition (Sperk, 1994, Unterberg et al., 2004, Simard et al., 2007). In addition, vasogenic edema formation results in the worsen consequence contributing to p

• In C elegans KDM A appears to be involved

  2022-01-07

  

  In C. elegans, KDM4A appears to be involved in H3K36me3 reduction on the X chromosome, suggesting that this protein has a relevant role in germ cell development (Figure 2A) (47). In addition, in HeLa cells, KDM4A is associated with the repression of the achaete-scute complex homologue 2 (ASCL2) gene

• br Histamine attenuates the cognitive impairing

  2022-01-07

  

  Histamine attenuates the cognitive impairing effects of early postnatal maternal deprivation Histamine acting on H2 receptors in the hippocampal CA1 region is able to reverse the deleterious effect of the exposure of rats to partial postnatal maternal deprivation on their memory consolidation of

• Another level of complexity within the TGF

  2022-01-07

  

  Another level of complexity within the TGF-ß/SMAD and Hippo/YAP/TAZ pathway crosstalks was recently uncovered. TGF-ß induces robust TAZ, but not YAP, protein expression in both mesenchymal and epithelial SCH727965 through a SMAD3-independent, p38/MAPK-dependent mechanism that triggers myocardin-rela

• Similarly towards the acylsulfamoyl benzoxaboroles the

  2022-01-07

  

  Similarly, towards the 5-acylsulfamoyl benzoxaboroles, the boronate intermediate was prepared according to , while the boronate , an intermediate towards 4-acylsulfamoyl benzoxaboroles, was prepared according to . The sulfonamides and used in the synthesis were made from the starting sulfonyl chlori

• Dendritic damage and loss of synaptic connections correlate

  2022-01-06

  

  Dendritic damage and loss of synaptic connections correlate with cognitive decline in HAND patients. Synapse loss induced by HIV proteins occurs early and via a different signaling pathway from that leading to neuronal death (Kim et al., 2008), suggesting that synapse loss might be a mechanism to re

• Generally speaking the regulation of GnIH on gonadotropins

  2022-01-06

  

  Generally speaking, the regulation of GnIH on gonadotropins synthesis and release, although controversial, could be direct and/or indirect via GnRH, among others peptides. In this sense, different scenarios have been reported in vertebrates. In mammalian and avian species, GnIH fibers reach the medi

• HSOR belonging to the aldoketo

  2022-01-06

  

  3α-HSOR, belonging to the aldoketo reductase superfamily, is a rate-limiting enzyme for the synthesis of 3α-reduced steroids, such as allopregnanolone and tetrahydrodeoxycorticosterone. 3α-HSOR was extensively expressed in the spinal dorsal horn and was upregulated following peripheral nerve injury,

• Neovascularization upon IMQ treatment was observed to

  2022-01-06

  

  Neovascularization upon IMQ treatment was observed to different degrees in WT and GAL3-KO mice, whereas the increase in vascular endothelial growth factor mRNA levels was genotype independent. Because we observed lower levels of the cytokines IL-17A, IL-22, IL-23, and TNF-α in IMQ-treated skin of GA

• br Materials and methods br Results Bgal

  2022-01-06

  

  Materials and methods Results Bgal from Alteromonas sp. ML117 had an open reading frame of 3126 bp encoding 1042 amino Evans Blue tetrasodium salt residues with a predicted mass of 120 kDa and a theoretical pI (isoelectric point) of 5.44. The recombinant Bgal contained a His tag, as well as o

15841 records 497/1057 page Previous Next First page 上5页 496497498499500 下5页 Last page