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Our perspective is not dissimilar from
2018-11-07
Our perspective is not dissimilar from Nelson\'s notion of interactive specialization of different organizing social forces at different times in development that shape social development. However, we place as much emphasis on evolutionary-based expectations of the social environment as the environm
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Coupling between vACC and PPC both at rest during the
2018-11-07
Coupling between vACC and PPC both at rest (during the rest baseline of a working memory task and during resting state fMRI) and during a working memory task have previously been shown to be associated with non-spatial working memory performance in adults (Hampson et al., 2006; Sambataro et al., 201
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A rich literature has identified a unique learning
2018-11-07
A rich literature has identified a unique learning circuit involved in the formation of attachment across a variety of species, although the neurobiology of attachment has mostly been described using rodents. Infant rodents, called pups, can neither hear nor see until the third week of life, and olf
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br Traumatic thoracolumbar spine fractures br Traumatic frac
2018-11-06
Traumatic thoracolumbar spine fractures Traumatic fractures of the thoracolumbar spine, particularly the thoracolumbar junction (T10–L2), are the most common fractures of the spinal column. Percutaneous pedicle screw instrumentation (PPSI) has been used for treating various trauma patterns. For
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In the present study there is
2018-11-06
In the present study, there is apparently no compensatory mechanism in visceral organs in order to overcome STZ induced oxidative stress. Reduced activities of SOD and CAT in liver, kidney and heart have been observed during diabetes. SOD is vital defence enzyme which catalyses the dismutation of su
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The oxidation of lipids proteins nucleic acids and carbohydr
2018-11-06
The oxidation of lipids, proteins, nucleic acids and carbohydrates generate a variety of damaging breakdown products which thus can lead to the onset of many degenerative diseases [11–15,62,63,69]. Lipid peroxidation of cell structures containing lipids can lead to the generation of different toxic
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Because cathepsins are located within lysosomes
2018-11-06
Because cathepsins are located within lysosomes and can be targeted by BA1, and because they participate in many cell death pathways, they are attractive candidates as effectors of charontosis in mESCs (Broker et al., 2004; Droga-Mazovec et al., 2008; Hsu et al., 2009; Kagedal et al., 2001; Zuzarte-
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As the stem cells were recovered
2018-11-06
As the stem somatostatin agonist were recovered from bears that recently were hibernating, it is possible that circulating factors that protect the bear from bone degeneration during hibernation prime the stem cells. That we did not see any chondrogenic differentiation in the cultures exposed to the
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Since topography of our lesion includes
2018-11-06
Since topography of our lesion includes cortical and sub-cortical areas, motor impairments of limb functioning and placing deficits were evaluated in the present study by foot fault test which has commonly been used as an efficient and sensitive test strategy for chronic assessment of skilled fore-
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br Results br Discussion Recent studies
2018-11-06
Results Discussion Recent studies have begun to investigate the role of Notch signaling in guiding cardiogenic fate decisions. Several studies have demonstrated that Notch inhibition through either expression of defective RBP-Jκ (Schroeder et al., 2003), Notch1-deficient mst2 (Nemir et al., 2
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Currently G CSF is the standard
2018-11-06
Currently, G-CSF is the standard of care for the treatment of bone marrow failure from unanticipated radiation exposure or following chemotherapy. The main therapeutic benefit of G-CSF is to enhance neutrophil recovery (Dainiak, 2010). It is less clear whether G-CSF is a direct mitigator of HSPC rad
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The highly conserved homeobox gene NKX is expressed from the
2018-11-06
The highly conserved homeobox gene NKX2-5 is expressed from the cardiac crescent stage of heart development and is maintained in the myocardial lineages throughout life (Harvey, 1996). Therefore, NKX2-5 expression can be used to isolate cardiac progenitors, immature cardiomyocytes and mature cardiom
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Introduction Embryonic pluripotent cells can give rise to di
2018-11-06
Introduction Embryonic pluripotent cells can give rise to differentiated progeny representing all three embryonic germ layers (Pera et al., 2000). Thus, embryonic stem (ES) cells are special primal structures in the body that retain two distinctive properties: the ability to self-renew through mito
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The identification of progenitor populations in the adult
2018-11-06
The identification of progenitor populations in the adult heart adds increased complexity to heart development, and raises many interesting questions – for example, are fetal or adult CPCs remnants of earlier embryonic progenitors, have they migrated in from other sources, or have they arisen de nov
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Acquiring an enriched population of
2018-11-06
Acquiring an enriched population of a given cell type using a fluorescence-based reporter line has many advantages but requires that the reporter expression is specific to the cell type to be enriched. Glial fibrillary acidic protein (GFAP) is a well-known marker for astrocytes; its expression is dy
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