• Introduction Primary thyroid lymphoma is rare accounting

  2018-10-29

  

  Introduction Primary thyroid lymphoma is rare, accounting for treatment planning. However, core-needle biopsy, which is less commonly used in thyroid-gland biopsies, may serve as a substitute to surgical biopsy. This study investigated the efficacy of various biopsy procedures and explored indicat

• br Conclusions br Introduction Inguinal hernias are

  2018-10-29

  

  Conclusions Introduction Inguinal hernias are very common in elderly male adults, but blunt contusion to the hernia causing intestinal perforation is rare. The computed tomographic (CT) scan has become an important diagnostic tool in evaluating abdominal injuries; however, physicians can over

• An year old man presented with

  2018-10-29

  

  An 87-year-old man presented with abrupt, severe lower abdominal pain and a pulsatile right hip mass. The patient had had chronic obstructive pulmonary disease and benign prostate hyperplasia for more than 2 decades. The patient had frequent bursts of vigorous productive coughing associated with his

• Associated hyperostosis of the anterior skull base is extrem

  2018-10-29

  

  Associated hyperostosis of the anterior skull corticotropin-releasing factor is extremely rare for patients with ENBs. Meningioma-associated hyperostosis is relatively common, generally localized, and proportional to the tumor size; the potential pathogenesis of tumor-associated hyperostosis was co

• br Offspring metabolic outcomes of maternal obesity high fat

  2018-10-29

  

  Offspring metabolic outcomes of maternal obesity/high-fat feeding Epigenetic mechanisms Epigenetic modifications are structural changes that occur to the DNA without changing the DNA sequence and can result in altered gene expression [59–63]. Epigenetic modifications of genes have been implica

• br Integrins Integrins are a large family

  2018-10-29

  

  Integrins Integrins are a large family of receptors which can bind ECM components, soluble extracellular ligands or other membrane bound cell surface molecules. In mammals, there are 24 known heterodimeric integrin receptors comprising of a non-covalent pairing of one of 8 β subunits with one of

• The critical role of Bmi in tumorigenesis has

  2018-10-29

  

  The critical role of Bmi1 in tumorigenesis has prompted investigations into genes upstream of this proto-oncogene. Several candidate genes have been reported to be upstream of Bmi1 in various cancer models. In neuroblastoma, MYCN and E2F-1 appears to be regulating Bmi1 Nilotinib (Ochiai et al., 2010

• br Conclusions The results of this study are significant for

  2018-10-29

  

  Conclusions The results of this study are significant for a deeper understanding of the cellular changes that take place during ex vivo expansion of BMSCs and ASCs, and appear to concur with current knowledge on the use of hypoxic environments and the occurrence of replicative senescence. Relevan

• br Results br Discussion TALEs are natural effector proteins

  2018-10-29

  

  Results Discussion TALEs are natural effector proteins secreted by Xanthomonas and Ralstonia bacteria. These proteins regulate gene expression in host plants and thus facilitate bacterial survival and colonization (Moscou and Bogdanove, 2009). TALE contains a DNA-binding domain consisting of 3

• Translational controls have a central role in the

  2018-10-29

  

  Translational controls have a central role in the regulation of stem cell biology. The importance of translational regulations has been reported in mouse embryonic stem cells, which display a considerable increase in mRNA levels and translation during their differentiation (Sampath et al., 2008). In

• A fourth challenge is that

  2018-10-26

  

  A fourth challenge is that the high level of regulatory variation across countries necessitates far-reaching forms of scientific self-governance, training and procedural adjustments in participating clinical trial sites (Rosemann, 2014b). A central reason for this is, that the existence of regulator

• br Results br Discussion We previously showed that metformin

  2018-10-26

  

  Results Discussion We previously showed that metformin treatment enhances murine adult neurogenesis in vivo without depleting the endogenous NPC pool (Wang et al., 2012). This finding has led to studies to repurpose metformin as a neuroregenerative agent to treat the injured or degenerating cl

• Zscan is sometimes considered as a

  2018-10-26

  

  Zscan4 is sometimes considered as a marker of highly pluripotent status, merely due to its expression at the two-cell stage during development (Cerulo et al., 2014). However, based on our observation, we would like to propose that the expression of Zscan4 is activated in response to telomere shorten

• Taken together these findings indicate

  2018-10-26

  

  Taken together, these findings indicate that basal-to-luminal differentiation can occur in prostate organogenesis, pathogenesis, and ex vivo assays, but rarely during normal tissue homeostasis. Thus, it has been unclear to what extent the plasticity of endogenous adult prostate basal dhpg in ex viv

• br Results br Discussion Yamanaka

  2018-10-26

  

  Results Discussion Yamanaka factors induce somatic cell reprogramming to iPSCs by promoting spatiotemporal expression of PSC-specific and metabolic genes. However, only a small fraction of these propyl complete full reprogramming, leaving most cells at an intermediate stage (Chan et al., 2009

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