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To address whether the bivalent state
2018-11-08
To address whether the bivalent state requires miRNAs or other Dicer-dependent functions, we reconstituted Dicer-deficient ESCs with miR-294, a member of the miR-290–295 miRNA family. ChIP-PCR showed that EZH2 binding was restored 48 hr later at the Gata3, Pax6, and Nr2f2 promoters (Figure 4B). Thus
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br Experimental Procedures br Author Contributions br Acknow
2018-11-08
Experimental Procedures Author Contributions Acknowledgments B.Z. was supported by an NYSTEM post-doctoral training fellowship, The SKI Stem Cell Research Facility is supported by NYSTEM grants C029153 and C024175 and The Starr Foundation. The work was further supported in part by NIH/NCI g
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In addition to configurations for constitutive gene expressi
2018-11-07
In addition to configurations for constitutive gene expression, we also tested the behavior of the Tet-on system (http://www.clontech.com) in which sequences encoding either GFP or mCherry expression were placed under the control of a doxycycline-responsive promoter. Although robust doxycycline-indu
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br Disclaimer br Funding br Conflicts
2018-11-07
Disclaimer Funding Conflicts Acknowledgments Introduction Racial health disparities are significant and convey real differences in life chances. Research in this area consistently shows that blacks in the United States live less healthier and much shorter lives than their similarly si
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br Introduction The burden of malaria
2018-11-07
Introduction The burden of malaria, currently estimated at over 2 million episodes of clinical disease and 655,000 deaths annually (WHO, 2012), has exerted strong selection on the human genome, leading to the occurrence at high frequencies of a number of host-protective polymorphisms (Kwiatkowski
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Como se desprende de la gr fica el esfuerzo
2018-11-07
Como se desprende de la gráfica 3, el esfuerzo de ajuste fiscal a partir de 2016 deberá ser muy grande, ya que un año después de la reforma energética de 2008, basada en leyes secundarias, que incluyó el relajamiento de la Ley Federal de Presupuesto y Responsabilidad Hacendaria en materia de manteni
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En este escrito s lo se exponen algunas
2018-11-07
En este escrito, sólo se exponen algunas evidencias de que en el contexto nacional y particularmente en el Distrito Federal, la falta de empleo formal y digno, al que tiene constitucionalmente derecho la población, ha sido compensado insustancialmente por la enorme cantidad de personas que realizan
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br Conclusiones Por lo tanto el gasto p blico
2018-11-07
Conclusiones Por lo tanto el gasto público en México es capaz de estimular la inversión privada, sí y solo sí éste es usado en sectores productivos. De acuerdo al análisis realizado, se da una expansión del ingreso público por concepto de tributación por medio del aumento en IVA e ISR, mismo que
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CEP-37440 br What is capitalism and neoliberalism Capitalism
2018-11-07
2. What is capitalism and neoliberalism Capitalism is a profit-making system in the short run, characterized by high productivity, competitive markets, private property, and the exploitation of labor. Whereas, from a theoretical standpoint, only one form of capitalism has existed, it has existed
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Schizophrenia is also characterized by abnormalities in the
2018-11-07
Schizophrenia is also characterized by abnormalities in the cortical circuitry underlying gamma oscillations elicited by a variety of stimuli and tasks (Uhlhaas et al., 2010). Especially, individuals with schizophrenia exhibit deficits in the auditory steady state response (ASSR) induced by gamma fr
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In the resting state the presence of neutrophils in
2018-11-07
In the resting state the presence of neutrophils in glomeruli would be minimal and thus VWF-cleaving activity by neutrophil proteases negligible. During infection and inflammation neutrophil influx will occur and proteases released into the glomerular capillary lumen will migrate towards the subendo
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pkc inhibitor McCaw et al s work adds important information
2018-11-07
McCaw et al.\'s work () adds important information to the growing knowledge regarding the effect of lipids on CLL cell biology, however numerous unknowns remain. For example, molecular prognostic markers in the CLL patients in these experiments are not fully detailed, LPL levels are unknown, and ser
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Glucocorticoids also exert non genomic
2018-11-07
Glucocorticoids also exert non-genomic actions that can occur rapidly within a period of several minutes. This is thought to occur through the activation of signal transduction pathways, or through the interactions of glucocorticoids with cellular membranes (Strehl and Buttgereit, 2013; Kadmiel and
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This study has several limitations First only papers publish
2018-11-07
This study has several limitations. First, only papers published in English were included. Publications in languages other than English were excluded due to insufficient information, which may lead to selection bias. Second, this study involved largely Asians and Caucasians; other ethnic subgroups (
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Although these data indicate the potential effectiveness of
2018-11-07
Although these data indicate the potential effectiveness of passive immunotherapy by NAbs, the successful development of preventive HIV-1 vaccines requires a thorough understanding of how Nabs are induced during HIV-1 infection. The unusual maturation features of NAbs make them extremely difficult t
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