Introduction The correct functioning of the

2018-10-20

Introduction The correct functioning of the epigenome ensures fidelity in the establishment of gene-expression programs that are compatible with specific cell identities. The need for tightly controlled epigenetic landscapes is of critical importance for stem cells, which are able to both self-rene

br Results br Discussion In the present

2018-10-20

Results Discussion In the present study we show that LPA1 is expressed by stem and progenitor Elesclomol (predominantly type 1 and type 2a) within the neurogenic niche of the dentate gyrus of adult mice, and that it outperforms Nestin, the current gold standard, as a marker for prospective is

Finally we tested whether the B cell differentiation defect

2018-10-20

Finally, we tested whether the B cell differentiation defect in the OsxCre;iDTR mutants could be rescued in vivo by intravenous administration of recombinant IL-7 and IGF-1. Both controls and mutants were subjected to daily injections of DT, DT + IL-7, or DT + IGF-1 for 12 days. At the end of the re

br Introduction Newborn neurons are continuously generated t

2018-10-20

Introduction Newborn neurons are continuously generated throughout life in several areas of the mammalian brain, including the subgranular zone (SGZ) of the hippocampal dentate gyrus (Imayoshi et al., 2008; Palmer et al., 1997; Zhao et al., 2008). Adult hippocampal neurogenesis is essential for n

IGF and PI K signaling

2018-10-20

IGF and PI3K signaling in regenerating muscle was tightly regulated across multiple levels and temporally, especially during the transition between myoblast proliferation and differentiation. In the early period, IGF1 was upregulated and quickly followed by increases in expression and chromatin remo

Here we attempted to reprogram highly fluorescence activated

2018-10-20

Here, we attempted to reprogram highly fluorescence-activated cell sorting (FACS)-purified (100% purity) leukemia blasts from three subtypes of B-ALL, t(4;11)/MLL-AF4+, t(1;11)+MLL-EPS15+, and t(12;21)/ETV6-RUNX1 B-ALL, to establish novel iPSC-based disease models to address the developmental impact

Hello world!

2018-07-29