• In Antirrhinum floral organ identity

  2024-04-19

  

  In Antirrhinum, floral organ identity genes include DEFICIENS (DEF) (Sommer et al., 1990) and GLOBOSA (GLO) (Trobner et al., 1992) required for petal and stamen identity (B-function), PLENA (P) required for stamen and carpel formation (C-function) (Bradley et al., 1993) and SQUAMOSA (SQUA) which is

• An unbiased evaluation of hepatic mRNA was performed to

  2024-04-18

  

  An unbiased evaluation of hepatic mRNA was performed to assess the impact of hepatocyte AMPK activation on the transcriptome. The expression of 913 genes were altered in control mice after chronic PF-06409577 treatment, 188 genes were affected by knocking out AMPK in hepatocytes, and expression of 2

• br Material and methods br Results br Discussion In

  2024-04-18

  

  Material and methods Results Discussion In order to find new and improved ways of treating type 2 diabetes (T2D) and other related conditions it is vital that investigators gain a more in-depth understanding of the effects that anti-diabetic treatments, such as TZDs, have on molecules impli

• enzastaurin br Available treatment modalities for individual

  2024-04-18

  

  Available treatment modalities for individuals with NAFLD There are several treatment modalities currently used or in clinical trials for individuals with NAFLD. The most widely recommended treatment is a lifestyle modification plan. As little as 5% weight loss has been shown to improve NASH hist

• br Materials and methods br Results

  2024-04-18

  

  Materials and methods Results Table 1 presents the metabolic phenotype of obese minipigs. After 60 d of HFHS feeding, minipigs not only showed an increased body weight (+45%), but also a perturbed muscarinic receptor antagonists homeostasis, with higher insulin levels (about +2-fold), HOMA-IR

• Pregnane X receptor PXR is a nuclear

  2024-04-18

  

  Pregnane X receptor (PXR) is a nuclear receptor that plays an important role in regulation of metabolism and disposition of structurally diverse xenobiotics as well as endogenous steroids and bile acids (Bertilsson et al., 1998, Kliewer et al., 1998, Lehmann et al., 1998). PXR regulates the metaboli

• br Acknowledgement This work was supported by grants from

  2024-04-18

  

  Acknowledgement This work was supported by grants from the American Heart Association Scientist Development Grant (SDG) to A. Elmarakby and 1R01EY023315-01 award to M. Al-Shabrawey. Introduction Inflammatory response is the result of a complex interaction between immune ubiquitin activating e

• Our analysis has devoted limited

  2024-04-18

  

  Our analysis has devoted limited attention to the standard corporate tax scheme with deductibility for interest payments that is in place in most countries. A conventional corporate tax scheme offers partial deduction of capital costs, and can be interpreted as a change in the degree of capital cost

• The first rationally designed dual

  2024-04-18

  

  The first rationally designed dual mPGES-1/5-LO inhibitor was reported in 2008 and represents a structural derivative of pirinixic ASC-J9 synthesis - a synthetic agonist of PPARα with lipid-lowering properties (Koeberle et al., 2008b). Further α-alkyl- and α-aryl-substituted derivatives have been sy

• Introduction Chronic inflammation is increasingly known as o

  2024-04-18

  

  Introduction Chronic inflammation is increasingly known as one of the most critical etiological factors in gastrointestinal (GI) cancers (Lee et al., 2016; Wang and Cho, 2015). Overexpression of 5-lipoxygenase (5-LOX), 5-LOX-activating protein (FLAP), as well as other leukotriene (LT) biosynthetic

• br The human CYP A gene is located on chromosome

  2024-04-18

  

  The human CYP17A1 gene is located on chromosome 10q24.3 (1) and spans 6.6 kb, which contain eight exons (2) and 1.6 kb of coding region. From this gene, the same 2.1-kb mRNA species is transcribed in both the adrenals and gonads (3), which yields a 57-kDa microsomal cytochrome P450c17 enzyme (CYP1

• Drug resistance development often involves structurally un

  2024-04-18

  

  Drug resistance development often involves structurally un-related drugs and, specifically both conventional and targeted agents. IGROV-1/Pt1 n oxide synthesis are characterized by resistance to cisplatin and reduced sensitivity to inhibitors of EGF-R and MEK, the up-stream activator of ERK1/2, ass

• br Acknowledgements This work was

  2024-04-18

  

  Acknowledgements This work was supported by the FedEx Institute of Technology at The University of Memphis (to DLB and ALP), NSF REU CHE 1156738 (to ALP in support of RSS), and NIHCA921060 (to GT). This material is based upon work supported by the National Science Foundation under Grant No. CHE-1

• br Economics consequences of antibiotic resistance in a SICU

  2024-04-17

  

  Economics consequences of antibiotic resistance in a SICU In the era of cost-containment, surgeons also need to consider the economic impact of antibiotic resistance in the surgical patient. Antibiotic-resistant infections are more difficult to treat, are more costly and more likely to be fatal t

• AR Vs are truncated AR proteins lacking the AR ligand

  2024-04-17

  

  AR-Vs are truncated AR proteins lacking the AR ligand-binding domain (AR-LBD) [6]. While AR-Vs have frequently been detected in CRPC, their expression and functional role in benign prostate tissues and primary prostate cancers is not readily apparent. Structural rearrangements in the AR gene and alt

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