• For some agonists these stable GPR responses were resistant

  2022-03-31

  

  For some agonists, these stable GPR119 responses were resistant to washing. Thus, sustained activation could continue, for at least a number of hours, even after removal of free agonist. These data are consistent with reports for other GPCR systems that do not desensitize (Calebiro et al., 2009, Fer

• Currently ursodeoxycholic acid UDCA is

  2022-03-31

  

  Currently, ursodeoxycholic 7ACC1 (UDCA) is the only recommended and widely used drug in the treatment of CFLD. However, the clinical efficacy of UDCA is controversial. The most recent Cochrane review only identified a small number of trials assessing the effectiveness of UDCA [92]. The authors concl

• Introduction Carbohydrates are some of the most stereochemic

  2022-03-31

  

  Introduction Carbohydrates are some of the most stereochemically complex biological molecules found in nature. In addition to their energetic and structural roles in living systems, their role when covalently linked to proteins is critically important in a myriad of molecular recognition processes.

• br Dysregulation of glutamate transporter expression and fun

  2022-03-31

  

  Dysregulation of glutamate transporter expression and function Aberrant glutamate transporter function and expression are associated with various neurological disorders. Therefore, understanding the underlying mechanisms of EAAT1/2 expression may provide therapeutic targets for treating neurologi

• br Materials and methods br Results br Discussion The

  2022-03-31

  

  Materials and methods Results Discussion The glucose transporter GLUT1 can be acutely activated or inhibited in L929 fibroblast Staurosporine by a wide variety of reagents or nutrient conditions [[9], [10], [11], [12],36,50]. This abrupt change in the activity of GLUT1 occurs within minute

• The effect of exercise on plasma ghrelin has previously been

  2022-03-30

  

  The effect of exercise on plasma ghrelin has previously been investigated mostly in humans using exercise regimens such as treadmill running, cycling, and rowing, and also in a few rodent studies and in some other animal models. While many of these clinical studies and some preclinical studies demon

• CaCl was from the Radiochemical Centre

  2022-03-30

  

  45CaCl2 was from the Radiochemical Centre (Amersham, UK), NaVO3 was from Reachim (Moscow, Russia). Tetrodotoxin was purchased from Calbiochem, DTNB from Merck, Darmstadt, Germany. Nifedipine was synthesized in the Institute of Drug Research, Modra, Slovakia and was kindly provided by Dr. Zdeno Mahrl

• rosavin Gap junctions mediate electrical coupling between ce

  2022-03-30

  

  Gap junctions mediate electrical coupling between cells by conducting direct ionic currents and thereby modulate their electrical activity (Hormuzdi et al., 2004). In the nervous system, electrical coupling organizes network activity by amplifying and synchronizing neuronal firing (Galarreta and Hes

• For functional metagenomics based gene

  2022-03-30

  

  For functional metagenomics-based gene screening, the DNA library construction approach is widely used . Fosmid and cosmid libraries are usually used to explore novel genes. Lee et al. reported that a halotolerant and protease-resistant α-galactosidase was identified from the gut metagenome of , a p

• br Introduction Farnesoid X receptor FXR is a bile

  2022-03-30

  

  Introduction Farnesoid X receptor (FXR) is a bile TRAM-34 regulated nuclear receptor highly expressed in the liver, intestine, kidney and adrenal glands in rodents.1, 2, 3, 4 FXR regulates transport proteins, the bile salt export pump (BSEP) and the organic solute transporter α (OSTα) that are in

• According to Laplace s law

  2022-03-30

  

  According to Laplace’s law, loss of myogenic response would increase wall stress and tension in downstream vessels and subsequently induce endothelial dysfunction and arterial stiffness [36]. Indeed, we found that arteries from FPR-1 KO mice presented with a leftward shift in the stress-strain curve

• Magtanong et al have demonstrated that MUFAs induce a ferrop

  2022-03-30

  

  Magtanong et al. (2019) have demonstrated that MUFAs induce a ferroptosis-resistant state in cells in an ACSL3 (acyl-CoA synthetase long-chain family member 3) dependent manner. They observed that MUFAs did not increase the expression of GPX4, which opposes ferroptosis. However, they blocked plasma

• br Memories can last a

  2022-03-30

  

  Memories can last a lifetime, long after the transient events have passed. The fact that information stored in the Lenalidomide can outlast the environmental trigger implies that enduring cellular changes in the central nervous system underlie memory. Epigenetic modifications of DNA and chromatin

• br Conflict of interest br Acknowledgments We

  2022-03-30

  

  Conflict of interest Acknowledgments We thank Professor Chen Rui (Southeast University, China) for providing plasmid P1P2N-HIF1. This study was supported by research grants from National Natural Science Foundation of China (81573189, 81730087). Introduction The consumption of large amounts

• Consideration must be given to both

  2022-03-30

  

  Consideration must be given to both the tissues themselves and to infiltrating immune cells. As highlighted by Maxwell and Eckardt [88], clinical trials of compounds targeting these pathways will require large numbers of participants and prolonged follow-up to identify rare and late complications or

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