• br Introduction Lichen forming fungi LFFs have evolved in va

  2022-01-14

  

  Introduction Lichen-forming fungi (LFFs) have evolved in various classes, including Arthoniomycetes, Coniocybomycetes, Dothideomycetes, Eurotiomycetes, Lecanoromycetes, Leotiomycetes and Lichinomycetes, in Ascomycota (James et al., 2006, Schoch et al., 2009a, Lumbsch and Rikkinen, 2017, Prieto et

• Overall ABC transporters are hypothesised to prevent the pen

  2022-01-14

  

  Overall, ABC transporters are hypothesised to prevent the penetration of AEDs and other pharmacological compounds into the brain, being a hurdle for therapeutic delivery in neurological diseases. DRE is thought to be in part related to an increased expression of efflux transporters in the BBB, altho

• 77 9 ICH induced striatal lesion produced

  2022-01-14

  

  ICH-induced striatal lesion produced a reduction of EAAT1 expression analogous to the decreased glutamate uptake at 6 h. The combined reduction of excitatory amino 77 9 transporters and of glutamate uptake activity might explain the well-known glutamate excitotoxicity following brain ischemia (Rao e

• Ionotropic glutamate receptors GluRs are ligand

  2022-01-14

  

  Ionotropic glutamate receptors (GluRs) are ligand-gated ion channels that mediate information processing at the majority of excitatory synapses in the brain and participate in such physiological processes as learning and memory, development and maintenance of cellular connections, and pain perceptio

• ZD6474 br Experimental section br Acknowledgments MIN cells

  2022-01-14

  

  Experimental section Acknowledgments MIN6 ZD6474 were kindly provided by Dr. Junichi Miyazaki, Osaka University. This research was supported in part by the Ministry of Education, Culture, Sports, Science and Technology of Japan (JP16H05099 and JP18H04609 to K.H., and JP16H06574 to T.U.), SENT

• br Glucose metabolism and diet Glucokinase is

  2022-01-14

  

  Glucose metabolism and diet Glucokinase is essential for sensing blood glucose levels, thus controls metabolism (Iynedjian, 1993, Iynedjian, 2009, Postic et al., 2001, Agius, 2008). Loss of glucokinase activity in humans and mice leads to diabetes (Printz et al., 1993b, Postic et al., 2001, Agius

• LbGlcK crystallized as a ligandless dimer in

  2022-01-14

  

  LbGlcK crystallized as a ligandless dimer in the asymmetric unit of space group P21 (Fig. 1a) with two identical subunits stabilized by a large contact surface area of 2295 Å2 (13% of the total surface area) as determined by the Protein Interfaces, Surfaces, and Assemblies (PISA) server [18]. Each m

• AKR D is very highly expressed

  2022-01-14

  

  AKR1D1 is very highly expressed in human liver and based upon the observations outlined above, with respect to other steroid hormone pre-receptor metabolising enzymes, it is entirely plausible that AKR1D1 could represent a critical regulatory step in the control of metabolic phenotype within the liv

• br Competing interests br Acknowledgements br Introduction

  2022-01-14

  

  Competing interests Acknowledgements Introduction - Factors Regulating Glucose Tolerance Strictly speaking, the incretin effect refers to the amplification of insulin secretion, which occurs when Torin1 synthesis is taken in orally as compared to infused intravenously [1]. Normally, the in

• MK cyclobutylpiperidin yl oxyphenyl methyl trifluoromethyl q

  2022-01-13

  

  MK-3134 (3-[4-(1-cyclobutylpiperidin-4-yl)oxyphenyl]-2-methyl-5-(trifluoromethyl)quinazolin-4-one) was synthesized by Merck, as the structurally constrained analogue of MK-0249 (Nagase et al., 2008). This H3R inverse agonist has MW 457.49, seven HBA, and MLogP 4.58, with one violation in terms of dr

• br Conclusion br Acknowledgments This research

  2022-01-13

  

  Conclusion Acknowledgments This research was funded by Tianjin Health Institution Key Projects, grant number 15KG148” and “Tianjin Medical University General Hospital Youth Incubation Fund, grant number ZYYFY2017029”. I would like to express my heartfelt gratitude to Professor Hongtao Zhang fo

• Another interesting approach is to

  2022-01-13

  

  Another interesting approach is to use partial agonists as starting point to develop specific antagonists like done in earlier decades [64], [65]. Possible indications for an attenuation of the NO/sGC signalling pathway might be specific neuronal disorders: an involvement in the aetiology of migrain

• It is well known that O

  2022-01-13

  

  It is well known that 12-O-tetradecanoylphorbol-13-acetate (TPA) is a tumor promoting agent of skin carcinogenesis in rodents [12]. TPA stimulates a variety of cellular functions in cancer cells, including cell motile activity [13], [14]. In our recent study, when liver epithelial cells were treated

• br Experimental br Acknowledgments This research

  2022-01-13

  

  Experimental Acknowledgments This research was supported by the Korea Research Foundation (2013R1A1A2007509). The authors thank to Dr. Moon Ho Son (Dong-A Pharm. Co. Ltd) for hGPR119 agonist activity assay. We also thank to Pharmacal Research Institute and Central Laboratory of Kangwon Nationa

• Several investigators including ourselves have previously

  2022-01-13

  

  Several investigators including ourselves have previously shown, that allogeneic HLA-DPB1 class II-alleles are powerful leukemia rejection Spectinomycin hydrochloride hydrate for CD4 T-cell therapy following allogeneic hematopoietic stem cell transplantation (Herr et al., 2017, Rutten et al., 2008,

15788 records 490/1053 page Previous Next First page 上5页 486487488489490 下5页 Last page