• br Making the BN Cox model computationally efficient

  2021-07-22

  

  Making the BN-Cox model computationally efficient One of the challenges to applying the BN-Cox model is an exponential growth of the conditional probability tables (CPT) corresponding to the survival variables, as the number of risk factors increases [22]. When the number of risk factors is high,

• br Multi hierarchical structure of collagen Protein structur

  2021-07-22

  

  Multi-hierarchical structure of collagen Protein structure is the foundation of protein functions and properties. It is generally accepted that the protein has biological function only when it has tertiary structure or above. Among the identified 28 types of collagen, most is known about type I c

• br Conclusion and future perspectives

  2021-07-22

  

  Conclusion and future perspectives LDL cholesterol-lowering therapy is essential for cardiovascular risk reduction. On the background of a high inter-personal variation of cholesterol synthesis and cholesterol ritodrine the efficacy of cholesterol lowering, both, with statins and with ezetimibe

• br Conclusion In conclusion our

  2021-07-22

  

  Conclusion In conclusion, our findings do not suggest that HT is an important determinant of future AD risk and are in line with a recent Cochrane review stating that HT is not indicated for preventing dementia or cognitive decline in postmenopausal women [13]. Contributors Conflict of inte

• It is now well accepted that increased

  2021-07-22

  

  It is now well accepted that increased local estrogen levels are associated with both the onset and growth of breast cancer. Tissue concentrations of estradiol (E2) in breast cancer are 10 times higher than that found in plasma [12]. Breast cancer tissues also contain increased activity and expressi

• Our finding that VEGF A induced downregulation of

  2021-07-22

  

  Our finding that VEGF-A induced downregulation of EphB4 is VEGFR2 dependent (Fig. 4A) is not surprising because VEGFR2 is the primary signaling receptor of VEGF-A in EC [34]. However, our finding that VEGF-A induced upregulation of dll4 Pacritinib is not inhibited by VEGFR2 inhibition suggests that

• Although information regarding the influence of PGE on

  2021-07-22

  

  Although information regarding the influence of PGE2 on cardiac fibroblast cell growth is sparse, the effect of PGE2 on other cell types has been studied extensively, particularly in cancer and cancer cell lines where COX-2 is over-expressed. Constitutive high levels of COX-2 expression have been no

• Potential break through technology poised to overcome these

  2021-07-22

  

  Potential break-through technology poised to overcome these above-mentioned limitations is that of the “substrate mediated enzyme prodrug therapy”, SMEPT (Fig. 1). Learning from the previously established enzyme prodrug therapies (EPT) and specifically the antibody-directed EPT (ADEPT) [12], develop

• br Methods br Results br Discussion The findings of this

  2021-07-22

  

  Methods Results Discussion The findings of this study indicate that an ET system including ET-1 and ET-2 as well as ET receptors are present in the retina and RPE/choroid, and are up-regulated by both hypertension and diabetes. Specifically, individual antagonism of the ETRA or ETRB deliver

• br GRAIL family Gene related to anergy in lymphocytes

  2021-07-22

  

  GRAIL family Gene related to anergy in lymphocytes protein (GRAIL, encoded by Rnf128 gene) is a transmembrane RING-type E3 ligase involved in T cell anergy and tolerance, and also regulation of Ezetimibe cytoskeletal organization [52]. This E3 was initially identified in CD4+ T helper cells and

• Generally glycines and other small residues such as alanine

  2021-07-22

  

  Generally, glycines (and other small residues such as alanine) present in a helical GxxxG-motif that are facing the same side of the helix form a uniform surface that enables direct contact with a second helix. Crystal structures of multipass membrane proteins have demonstrated that GxxxG-motifs are

• br Acknowledgements The study of RING type E s

  2021-07-22

  

  Acknowledgements The study of RING-type E3s continues to grow extremely rapidly. We regret that it was possible to only cite a fraction of the outstanding primary publications in this field. This work was supported by the National Institute of General Medical Sciences grants R01 GM088055 and R01

• br Chain specific ubiquitin probes The conventional

  2021-07-22

  

  Chain specific ubiquitin probes The conventional way of assessing linkage specificity is by measuring turnover rates of different diubiquitin molecules as substrates. Although this method has been applied successfully in several studies [7••, 8] it is limited to isolated DUBs, whereas linkage spe

• Diacylglycerol kinase was one of the hits identified from th

  2021-07-21

  

  Diacylglycerol kinase was one of the hits identified from the RNAi screen. Diacylglycerol kinases are conserved across a MRT68921 of species with more complex, multicellular organisms possessing several DGKs with differing protein domains, expression patterns and functions [61], [62], [63]. Some of

• Interest in DGKs increased as it became clear that

  2021-07-21

  

  Interest in DGKs increased as it became clear that not only are they important for lipid homeostasis, they serve to modulate the relative levels of diacylglycerol (DAG) and phosphatidic Dexmedetomidine (PtdOH) that play critical roles in a variety of signaling pathways (Eichmann and Lass, 2015; Liu

15956 records 603/1064 page Previous Next First page 上5页 601602603604605 下5页 Last page