• Several tertiary prevention studies are currently underway e

  2024-09-29

  

  Several tertiary prevention studies are currently underway examining the use of dutasteride for prostate cancer treatment: (1) during expectant management of prostate cancer, (2) after radical prostatectomy in men at high risk for relapse, and (3) in men with metastatic disease. The Reduction by Dut

• The discovery of acetylsalicylic acid aspirin in paved the w

  2024-09-29

  

  The discovery of acetylsalicylic (+)- Corydaline (aspirin) in 1897 paved the way for the development of classical NSAIDs as first-line therapeutics for anti-inflammatory, anti-pyretic and analgesic therapy. Large efforts have been made in the following decades to improve the efficacy and in particu

• The most likely explanation for the species differences

  2024-09-28

  

  The most likely explanation for the species differences in aromatase distribution and the unique calcium calmodulin dependent protein kinase distribution in humans is the unique location, size and highly elaborate organization of the human aromatase gene (e.g. Bulun et al., 2003). The human Cyp19 i

• Therefore the rational design of target

  2024-09-28

  

  Therefore, the rational design of target compounds is based on the hybrid of attractive phenotypic bis-indole (5, Fig. 1) and sulfonamide moieties, in which the indole core might anticipate in hydrophobic interaction, and the functionality of sulfonamide group may involve in H-bonding with the site

• br Conflicts of interest br Introduction Arginase catalyzes

  2024-09-28

  

  Conflicts of interest Introduction Arginase catalyzes the reaction in which l-arginine is converted to l-ornithine and urea. In humans, two arginase isoenzymes have been identified, arginase 1 and arginase 2, that differ in cellular location and tissue distribution [1]. Both arginase enzymes a

• We further conducted stratified analyses to observe changes

  2024-09-28

  

  We further conducted stratified analyses to observe changes in enzyme levels across the periods by subgroups. Fig. 1 shows the changes in GPx levels by subgroups of age, sex, and smoking status. In all participants, GPx levels decreased when air pollution levels declined but increased after the Olym

• br Findings br Discussion br Conclusions Midwives

  2024-09-28

  

  Findings Discussion Conclusions Midwives were more likely to provide effective antimalaria services (including two doses of IPT during the second and third trimesters of pregnancy) to pregnant women if Conflict of interest Authors’ contributions Funding Acknowledgements Resea

• Regarding progression free survival analyzing clinical trial

  2024-09-28

  

  Regarding progression free-survival, analyzing 12 clinical trials, we demonstrated that the use of antiangiogenic treatment results in a statistically longer PFS with a pooled HR of 0.76 (95% CI 0.65–0.89, p2016). Another Mitochondrial DNA Isolation Kit of improvement of PFS only is that after anti

• Although sex hormones activational effects are known to dire

  2024-09-28

  

  Although sex hormones (activational effects) are known to directly interact with RAS (Baiardi et al., 2005, Miller et al., 1999, Silbiger and Neugarten, 1995), the potential contribution of organizational hormonal and SCC effects on physiological sex-based difference in the regulation of the RAS rem

• The loss of synaptic proteins such

  2024-09-28

  

  The loss of synaptic proteins such as synaptophysin from the aromatase inhibitor is indicative of synapse degeneration and provided a good correlate of the degree of dementia in AD [12], [13], [14]. Consequently, the loss of synaptic proteins from cultured primary neurons incubated with Aβ provides

• br Perspective AA LA and other PUFAs and their lipid

  2024-09-28

  

  Perspective AA, LA and other PUFAs and their lipid metabolites play an important role in human diseases. 12/15-LOX which is the metabolic enzyme of them plays an important role in the pathogenesis-related diseases such as atherosclerosis, diabetic nephropathy, neurological diseases and other path

• Aberrant lipid levels are associated

  2024-09-28

  

  Aberrant lipid levels are associated with various disorders, including vascular diseases and diabetes. Furthermore, important events support the idea that lipids, especially cholesterol and its derivatives, have a fundamental role in the physiopathology of AD. The Cycloheximide is rich in cholester

• br Materials and method br Result and

  2024-09-28

  

  Materials and method Result and discussion Conclusion Acknowledgments This work is partly supported by the University Research Committee (URC) of the Senate of The Federal University of Technology, Akure. The authors thanked IFS for the funds (F/4449 1F and F/4449-2F) used to purchase th

• With one exception all receptors for dopamine DA

  2024-09-28

  

  With one exception, all receptors for dopamine (DA), serotonin (5-hydroxytryptamine, 5-HT), and norepinephrine are metabotropic receptors. The five metabotropic DA receptors (D1–D5) in the CNS are involved in motivation, pleasure, cognition, learning, memory, fine motor control, and modulate neuroen

• br Functional consequences of ADK

  2024-09-27

  

  Functional consequences of ADK regulation on astrocyte function As outlined above (see introduction), ADK critically regulates the extracellular adenosine levels in hedgehog inhibitor (Boison, 2006, Etherington et al., 2009). Changes in the levels of adenosine, as a result of the regulation of AD

15809 records 74/1054 page Previous Next First page 上5页 7172737475 下5页 Last page