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The functions of HMGN protein
2024-08-31
The functions of HMGN1 protein are modulated by various post-translational modifications, including phosphorylation , , , acetylation , and glycosylation . Phosphorylation in HMGN1 may influence its binding affinity to DNA or nucleosome-associated proteins and affect the sub-cellular localization an
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Overall we found maternal antibiotics
2024-08-31
Overall, we found maternal ML385 australia to be associated with improved outcomes. In these multiple logistic regression models, high postnatal empiric infant antibiotic exposure was not significantly associated with risk for NEC or LOS. However, consistent with previous studies,5, 6 receipt of hi
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As patients with type diabetes
2024-08-30
As patients with type 2 diabetes are known to be hyperinsulinemic per se, this relationship between insulin/IGF1 receptor and AR may point towards a causal role of insulin in AR upregulation. Indeed, this is supported by several previous observations. Beyond the already mentioned AR activation by in
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br Conclusions Our study confirms that N
2024-08-30
Conclusions Our study confirms that N-terminal mutations can affect Aβ fibril and oligomer formation, despite lying outside the core amyloid region of Aβ. Of the three factors that may influence Aβ-mediated toxicity (primary structure of Aβ, assembly structure and cellular responses), our results
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br Introduction The structural similarities between puromyci
2024-08-30
Introduction The structural similarities between puromycin (1, Fig. 1) and the aminoacyl adenyl terminal of aminoacyl–tRNA allow it to terminate the protein synthesis process by causing premature release of a polypeptide from the ribosome [1], [2]. Tremendous progress in the study of puromycin an
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br Experimental procedure br Introduction
2024-08-30
Experimental procedure Introduction Migraine is a debilitating neurovascular disorder characterized by recurring unilateral pulsating headaches of moderate to severe intensity, associated with nausea, photophobia and/or phonophobia, lasting from 4 to 72 h (Headache Classification Committee of
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AZD6738 In this study an in
2024-08-30
In this study, an in vitro AChE inhibition assay combined with UF-HPLC-ESI-Q-TOF/MS method was developed for rapid screening and identification of AChEI from the roots of C. chinensis Franch. Five compounds was found with AChE inhibitory activity and identified by the on-line DAD-ESI-Q-TOF/MS compar
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Polydatin In fact serotonin is a major modulator
2024-08-30
In fact, serotonin is a major modulator of dopaminergic (DA) neuronal activity through the 5-HT2C receptor. Studies have shown that the selective 5-HT2C receptor agonist Ro60-0175 blocks the burst-firing of mesolimbic DA neurons, which project from the ventral tegmental area (VTA) to the nucleus acc
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We demonstrate a role for low oxygen to
2024-08-30
We demonstrate a role for low oxygen to regulate ATX mRNA in hepatocyte-derived HuH7 triphosphate sodium and human liver slices, consistent with reports of increased ATX expression in a variety of tumours that are frequently hypoxic. Importantly, we show a positive association between elevated ATX m
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br Acknowledgments br Introduction Human innate immune
2024-08-29
Acknowledgments Introduction Human innate immune system provides first line of defense against multiple viral or bacterial attacks, and provides critical surveillance against oncogenic development. Evidences show that individuals with primary immunodeficiency or induced immunosuppression durin
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EDTA Serum concentrations of acute phase
2024-08-29
Serum concentrations of acute phase proteins (APP) and of antioxidants have proved to be clinically useful biomarkers of pyometra in different species, including bitches, cows and mares [[11], [12], [13], [14], [15]]. Acute phase proteins are being increasingly used in both human and veterinary medi
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AR is expressed in cell specific human ovarian
2024-08-29
AR is expressed in cell-specific human ovarian follicles at all stages of follicular development [25]. Administration of androgens in animals demonstrated initiation of follicular recruitment, stimulation of early stages of follicular growth, and increase in the number of growing follicles [26,27].
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LAP locations in the parasite tissues would provide
2024-08-29
LAP locations in the parasite tissues would provide clues for the potential physiological roles of it inside the parasite body. To date, tissue localization of LAPs has been carried out in many helminth parasites; however, information regarding LAPs in tapeworm is scarce. It was shown that LAPs were
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br A and tau in Alzheimer s disease The
2024-08-29
Aβ and tau in Alzheimer's disease The two classical histopathological hallmarks of AD are extracellular insoluble Aβ deposits, known as Aβ plaques, and intracellular accumulations of insoluble microtubule-associated tau protein, known as neurofibrillary tangles [14]. Aβ peptides are produced as a
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Introduction Lipoxygenases LOXs are key enzymes that catalyz
2024-08-29
Introduction Lipoxygenases (LOXs) are key enzymes that catalyze the polyunsaturated fatty acids (PUFAs) such as arachidic Glutathione (GSH/GSSG/Total) Fluorometric Assay Kit (AA), linoleic acid (LA) and others unsaturated fatty acids (Brash, 1999). LOXs are expressed in immune, neural, epithelial,
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