• Our results lead to the discovery and characterization of

  2024-08-29

  

  Our results lead to the discovery and characterization of VvAAT2, a gene potentially involved in acetate accumulation in grape berries discovered through amino-acid feeding experiments. Incubation with exogenous amino acids has also been a key in the discovery of new genes affecting fruit aromas [13

• The mechanisms that control Ahr transcription are poorly und

  2024-08-29

  

  The mechanisms that control Ahr transcription are poorly understood, especially when considering cell type-specific regulation. A recent report suggested that the Ahr transcription might be directly promoted by RORγt [retinoic Costunolide receptor (RAR)-related orphan receptor γt] based on ChIP-Seq

• br Therapeutic advantages and clinical implications of caffe

  2024-08-29

  

  Therapeutic advantages and clinical implications of caffeine treatment in ROP The demonstration of the role of the adenosine receptor in development of ROP and protection by caffeine suggests two potential therapeutic strategies with high translational potential: a) modification of caffeine treat

• br LOX in pancreatic cancer

  2024-08-28

  

  5-LOX in pancreatic cancer 5-LOX is a key player in pancreatic cancer (PC) progression. The upregulation of 5-LOX mRNA has been observed in pancreatic adenocarcinoma (PDAC) and also in neoplastic pancreatic tissues (Kennedy et al., 2003). Higher levels of 5-LOX transcripts (messengers) are presen

• Several tertiary prevention studies are currently underway e

  2024-08-28

  

  Several tertiary prevention studies are currently underway examining the use of dutasteride for prostate cancer treatment: (1) during expectant management of prostate cancer, (2) after radical prostatectomy in men at high risk for relapse, and (3) in men with metastatic disease. The Reduction by Dut

• br Funding br Introduction The interest in the effects of

  2024-08-28

  

  Funding Introduction The interest in the effects of endocrine disrupting chemicals (EDCs) in the aquatic environment continues to increase over the past decade, specifically those that act on steroidogenic pathways. EDCs that include synthetic androgenic and estrogenic compounds can severely a

• br Materials and methods br Results br

  2024-08-28

  

  Materials and methods Results Discussions Our results indicated that autophagy was suppressed in GECs under HAGG treatment, through Akt/mTOR-dependent pathways. Previous reports provided clues for the linkages between ICs and endothelial cell autophagy. Fujii and colleagues reported that se

• Several in vivo and in vitro studies have demonstrated

  2024-08-28

  

  Several in vivo and in vitro studies have demonstrated changes in bioactive lipid profiles under hyperglycemic conditions and have linked these changes with increased leukocyte adhesion and vascular dysfunction during diabetes. This input has originated partly from lipidomic studies that showed elev

• br The role of apelin in cancer Studies on cancers

  2024-08-28

  

  The role of apelin in cancer Studies on cancers are intensively conducted worldwide. It is thought that this large family of diseases is among the most studied. The researchers test newly-discovered substances hoping to find remedies and diagnostic indices for this illness. One of such substances

• Patients with cardiovascular disorders typically have

  2024-08-28

  

  Patients with cardiovascular disorders typically have lower plasma apelin levels than matched healthy controls. For example, plasma apelin levels are reduced in patients with coronary artery disease (CAD), and among CAD patients with unstable angina or acute myocardial infraction there is a further

• Therefore a number of homoisoflavonoids may be designed in f

  2024-08-28

  

  Therefore, a number of homoisoflavonoids may be designed in future that may be effective against angiogenesis for treating ocular neovascularization. As this gallic acid current study deals with robust molecular modeling techniques on SH-11037 (cpd 15) and related homoisoflavonoids and SH-11037 has

• In receptor binding terminology both receptor

  2024-08-28

  

  In receptor binding terminology, both receptor and acceptor contain a receptive site for the ligand, although only the receptor induces a biological function. Moreover, the acceptor lacks an endogenous ligand. Many proteins have been described as receptors for toxic Aβ assemblies, implying a designe

• Hepatic inflammation and fibrosis are hallmarks of the NASH

  2024-08-28

  

  Hepatic 3'-O-(2-nitrobenzyl)-2'-dATP and fibrosis are hallmarks of the NASH phenotype and are thought to occur in a subset of patients with NAFLD. While it is hypothesized that therapeutic lowering of hepatic lipids will be sufficient to improve hepatic fibrosis and inflammation secondarily, this r

• Our results lead to the discovery and characterization

  2024-08-27

  

  Our results lead to the discovery and characterization of VvAAT2, a gene potentially involved in acetate accumulation in grape berries discovered through amino-acid feeding experiments. Incubation with exogenous amino acids has also been a key in the discovery of new genes affecting fruit aromas [13

• Due to metabolic variations it is important to consider argi

  2024-08-27

  

  Due to metabolic variations, it is important to consider arginine metabolism and dependency in specific contexts to identify precise patterns. This is best illustrated for ASS: while ASS deficiency correlates with worse prognosis in sarcomas, ASS levels positively correlate with a poor prognosis in

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